Browsing Bergen Open Research Archive by Author "Herrera, Pedro L."

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    • Islet cell replacement and transplantation immunology in a mouse strain with inducible diabetes 

      Bhagchandani, Preksha; Chang, Charles A.; Zhao, Weichen; Ghila, Luiza Mihaela; Herrera, Pedro L.; Chera, Simona; Kim, Seung K. (Journal article; Peer reviewed, 2022)
      Improved models of experimental diabetes are needed to develop cell therapies for diabetes. Here, we introduce the B6 RIP-DTR mouse, a model of experimental diabetes in fully immunocompetent animals. These inbred mice ...

    • Stage-specific transcriptomic changes in pancreatic α-cells after massive β-cell loss 

      Oropeza, Daniel; Cigliola, Valentina; Romero, Agustín; Chera, Simona; Rodríguez-Seguí, Santiago; Herrera, Pedro L. (Journal article; Peer reviewed, 2021)
      Background Loss of pancreatic insulin-secreting β-cells due to metabolic or autoimmune damage leads to the development of diabetes. The discovery that α-cells can be efficiently reprogrammed into insulin-secreting cells ...